Unlike other nutritional supplements, the potency or efficacy of an enzyme is not measured by weight or concentration, because the number of milligrams of any enzyme would not determine its true efficacy. The enzyme activity is measured using “Activity units” and is generally determined by various assays (test methods) that are performed under specific conditions.
The accepted national standards of the U.S. Food and Drug Administration (testing methodologies) for determining enzyme potency are defined in the Food Chemical Codex (FCC) and published by the National Academy Press, Washington, D.C. This system establishes activity levels and potency for enzymes.
Activity Units of Digestive Enzymes
| Enzyme | Activity Units as per FCC |
Enzyme Activity (Unit/g) |
|---|---|---|
| α-Amylase | DU | 24000 U/g (Dextrinizing Unit/g) |
| Cellulase | CU | 1100 CU/g (Cellulase Unit/g) |
| Lipase | FIP | 200 FIP/g (Fédération Internationale Pharmaceutique Unit/g) |
| Lactase | ALU | 4000 ALU/g (Acid Lactase Unit/g) |
| Neutral Protease | PC | 6000 PC/g (Protease Unit on L-tyrosine basis/g) |
Understanding Enzyme Activity
Enzyme potency is measured in units of activity, not weight. Activity reflects the enzyme’s functional capacity: specifically, its ability to act on its target substrate (proteins, fats, or carbohydrates) under defined conditions. This makes activity the most meaningful measure of an enzyme ingredient’s value in a formulation.
DigeZyme® enzyme components are tested and characterized for activity using standardized methods, supporting consistent performance across production batches. Brands formulating with DigeZyme® can rely on activity-based quality specifications when developing finished products.